What's Inside Potent, Pure & Purposeful
Every ingredient is selected not just for what it is, but for how directly it supports your missing progesterone and restores your PCOS cycle.
All ingredients are added in their most bioavailable and nutrient-rich form — unlike many brands that cut corners with the cheapest versions in doses too low to make a real difference.
☆ No Synthetic Hormones
✓ 100% Natural / No Chemicals
⌘ Organic — Non GMO
Dioscorea Villosa (Wild Yam) Root Extract
The engine of the formula. Our wild yam is sourced in its purest form, delivering the highest concentration of diosgenin — the plant compound your body uses to support natural progesterone production. This is the hormone PCOS women are almost always deficient in, and the reason your cycle stalls in the second half. Every other ingredient in this cream exists to support what this one starts.
Trifolium Pratense (Red Clover Blossom) Extract
Rich in isoflavones, red clover works alongside wild yam to help modulate estrogen activity — which matters because PCOS isn't just low progesterone, it's progesterone low relative to estrogen. This ingredient helps rebalance that ratio so your body stops living in estrogen dominance and starts completing cycles the way it should.
Vitex Agnus-Castus (Chasteberry) Extract
The most studied herb in female cycle regulation. Vitex acts on the pituitary gland to increase luteinizing hormone and support progesterone production during the luteal phase — the exact phase that's cut short or missing entirely in most PCOS women. In clinical studies, vitex has been shown to help restore ovulation and improve cycle regularity. It's the ingredient your naturopath would recommend first, and it's already in here.
If you've tried everything and nothing's worked, we get it.
You've attacked insulin with inositol. Androgens with spearmint. You've stacked berberine, NAC, vitex capsules, and omega-3s — and your cycle is still a guessing game. That's because most PCOS supplements target the symptoms everyone talks about while ignoring the hormonal gap underneath: collapsed progesterone. And even the products that claim to support progesterone are oral — meaning your already-compromised PCOS gut absorbs a fraction of what you swallow. You've been putting the right intent into the wrong delivery system.
Second Harmony delivers diosgenin — nature's progesterone precursor — directly through your skin, bypassing your gut entirely. Every ingredient is in its most bioavailable form, so your body actually receives and uses it — no cheap fillers, no token doses, no eighth pill on the pile. Every jar is triple-tested for authenticity, potency, and safety. And because it's 100% plant-based with zero synthetic hormones or birth control chemicals, your body isn't being overridden — it's being supported. This isn't another supplement hoping to nudge your insulin and pray your cycle follows. This is progesterone support, delivered directly, filling the exact gap that's been keeping your period hostage.
Life-changing results in weeks
Frequently asked questions
Not at all. Second Harmony works alongside your existing routine — it's not competing with your supplements, it's filling the gap they can't reach. Inositol and berberine target insulin and blood sugar. That matters. But none of them directly support progesterone, which is the hormone responsible for completing your cycle. Think of it this way: your supplements are doing important work on one side of the equation, but your cycle won't regulate until the progesterone side gets addressed too. Most of our customers actually find they're able to simplify their stack over time once their cycle stabilizes — but that's a conversation between you and your body.
Birth control doesn't restore your natural cycle — it replaces it with a synthetic one. The "period" you get on the pill is a withdrawal bleed, not ovulation. The moment you stop, your irregular cycles come right back because nothing was actually fixed underneath. Second Harmony takes the opposite approach. Instead of overriding your hormones, it delivers diosgenin through your skin to support your body's own progesterone production — so your cycle restarts naturally, on its own terms. No synthetic hormones, no shutting down your reproductive system, no dreading what happens when you stop.
Every woman's body is different, but here's what our customers typically report. Within the first 2-3 weeks, many notice subtler shifts — less bloating, more stable mood, brain fog starting to lift. By month two, most women see a real change in their cycle length or get a full period for the first time in months. By month three, many are tracking consecutive regular cycles. We always recommend committing to at least 90 days. Your hormones didn't fall out of balance overnight, and the cream works by supporting your body's natural rhythm — not forcing a response. The women who get the best results are the ones who stay consistent with nightly application and give their bodies time to respond.
We understand the skepticism — PCOS women get sold miracle cures constantly. Here's what we know: wild yam contains diosgenin, a plant-derived compound that has been studied for decades for its role in supporting steroid hormone pathways, including progesterone. Diosgenin is actually the same compound pharmaceutical companies originally used to synthesize progesterone in the lab. The difference is that Second Harmony delivers it topically in its natural form, allowing your body to utilize it through the skin rather than the digestive system. We're not claiming this is a drug or a cure for PCOS. What we are saying is that thousands of women with PCOS have reported real, measurable cycle improvements — and the mechanism behind why it works is well-documented. We believe your cycle tracker will be the only clinical trial you need.
Most progesterone creams on the market are either synthetic progestins (which behave differently in your body than natural progesterone) or they're generic "hormone balance" creams with trace amounts of wild yam buried under fillers and fragrance. Second Harmony is formulated specifically with a concentrated diosgenin-rich wild yam extract as the primary active ingredient — not an afterthought. The delivery also matters. Many women apply progesterone creams inconsistently or to the wrong areas. We recommend applying to thin-skinned pulse points like the inner wrists, inner arms, or behind the knees before bed every night. Consistency and placement are everything. The cream itself is only half the equation — how and where you use it is the other half, and we walk you through exactly how to get the most from every application.